[HTML][HTML] Circulating type I interferon levels in the early phase of COVID-19 are associated with the development of respiratory failure

K Nagaoka, H Kawasuji, Y Murai, M Kaneda… - Frontiers in …, 2022 - frontiersin.org
Background The role of type I interferons (IFNs) in the early phase of COVID-19 remains
unclear. Objectives To evaluate the relationship between IFN-I levels in patients with COVID …

[HTML][HTML] Blood interferon-α levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients

M Contoli, A Papi, L Tomassetti, P Rizzo… - Frontiers in …, 2021 - frontiersin.org
Background: Deficient interferon responses have been proposed as one of the relevant
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …

Type I and III interferons are good markers to monitor COVID-19 pathophysiology

D Darif, R Ejghal, C Desterke, A Outlioua, I Hammi… - Cytokine, 2023 - Elsevier
The COVID-19 pandemic has caused millions of deaths and has resulted in disastrous
societal and economic impacts worldwide. During SARS-CoV-2 infection, abnormal levels of …

[HTML][HTML] Functional exhaustion of type I and II interferons production in severe COVID-19 patients

C Ruetsch, V Brglez, M Cremoni, K Zorzi… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has emerged in Wuhan in December 2019 and has since …

[HTML][HTML] Circulating type I interferon levels and COVID-19 severity: a systematic review and meta-analysis

RP Da Silva, JIB Gonçalves, RF Zanin… - Frontiers in …, 2021 - frontiersin.org
Introduction Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections, resulting in a range of clinical …

[HTML][HTML] Serum levels of type I interferon (IFN-I) is associated with the severity of COVID-19

Y Sun, G Wang, R Wang, L Ren… - Journal of Medical …, 2023 - microbiologyresearch.org
Introduction. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection, coronavirus disease 2019 (COVID-19) has threatened global public health …

Downregulation of type III interferons in patients with severe COVID‐19

Y Fukuda, T Homma, H Inoue… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing
burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was …

[HTML][HTML] Expression of IFN-Gamma is significantly reduced during severity of covid-19 infection in hospitalized patients

S Mansoor, AR Butt, A Bibi, S Mushtaq, I Ullah… - Plos one, 2023 - journals.plos.org
Cytokines play an important role in SARS-CoV-2 infection progression and severity. A
number of inflammatory cytokines have been directly associated with disease severity …

[HTML][HTML] A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients

MS Soltani-Zangbar, F Parhizkar, E Ghaedi… - Cell Communication and …, 2022 - Springer
Background The COVID-19 pandemic has become the world's main life-threatening
challenge in the third decade of the twenty-first century. Numerous studies have been …

[HTML][HTML] Predictive values of immune indicators on respiratory failure in the early phase of COVID-19 due to Delta and precedent variants

K Nagaoka, H Kawasuji, Y Takegoshi, Y Murai… - Frontiers in …, 2023 - frontiersin.org
Background Immune response indicators in the early phase of COVID-19, including
interferon and neutralizing responses against SARS-CoV-2, which predict hypoxemia …