Shared genetic loci between schizophrenia and white blood cell counts suggest genetically determined systemic immune abnormalities

NE Steen, Z Rahman, A Szabo… - Schizophrenia …, 2023 - academic.oup.com
Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-
wide association studies (GWAS) have identified genetic variants associated with SCZ and …

[HTML][HTML] Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

OA Andreassen, HF Harbo, Y Wang… - Molecular …, 2015 - nature.com
Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent
genome-wide association studies (GWAS) have identified immune-related single-nucleotide …

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases

JG Pouget, VF Gonçalves… - Schizophrenia …, 2016 - academic.oup.com
There has been intense debate over the immunological basis of schizophrenia, and the
potential utility of adjunct immunotherapies. The major histocompatibility complex is …

[HTML][HTML] Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study

C Wang, D Zhu, D Zhang, X Zuo, L Yao, T Liu, X Ge… - BMC psychiatry, 2023 - Springer
Background Complex immune-brain interactions that affect neural development, survival
and function might have causal and therapeutic implications for psychiatric illnesses …

[HTML][HTML] The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study

Z Gao, B Li, X Guo, W Bai, C Kou - BMC psychiatry, 2023 - Springer
Background Positive associations between the risk of schizophrenia and the level of white
blood cells (WBC) count have been suggested by observational studies. However, the …

[HTML][HTML] Genetic liability for schizophrenia predicts risk of immune disorders

S Stringer, RS Kahn, LD de Witte, RA Ophoff… - Schizophrenia …, 2014 - Elsevier
Background Schizophrenia patients and their parents have an increased risk of immune
disorders compared to population controls and their parents. This may be explained by …

The emerging immunogenetic architecture of schizophrenia

JG Pouget - Schizophrenia bulletin, 2018 - academic.oup.com
Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have
long been proposed to contribute to the development of schizophrenia, and accumulating …

Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk

JG Pouget… - Human Molecular …, 2019 - academic.oup.com
Many immune diseases occur at different rates among people with schizophrenia compared
to the general population. Here, we evaluated whether this phenomenon might be explained …

[HTML][HTML] Associations between SNPs and immune-related circulating proteins in schizophrenia

MK Chan, JD Cooper, S Heilmann-Heimbach… - Scientific Reports, 2017 - nature.com
Genome-wide association studies (GWAS) and proteomic studies have provided convincing
evidence implicating alterations in immune/inflammatory processes in schizophrenia …

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

M Ahangari, E Everest, TH Nguyen, BC Verrelli… - Brain, Behavior, and …, 2022 - Elsevier
Common genetic variants identified in genome-wide association studies (GWAS) show
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …