Prostate cancer is a common malignancy in men, which transforms into castration-resistant
prostate cancer (CRPC) after androgen deprivation therapy (ADT). However, the optimal …

Purpose Prostate cancer remains a leading cause of cancer-related deaths among men
worldwide, driving the need for innovative therapeutic avenues. Despite preliminary …

We examined the anti-cancer effects and molecular mechanism of simvastatin in human
castration-resistant prostate cancer (CRPC) cells, particularly focused on LIN28B and its …

Prostate cancer (PC) is the second leading cause of cancer-related death among men.
Treatment of PC becomes difficult after progression because PC that used to be androgen …

NF-κB transcription factors critically regulate the expression of genes which are involved in
important cellular processes, including cellular proliferation and apoptosis. Abnormal …

BK002 consists of Achyranthes japonica Nakai (AJN) and Melandrium firmum Rohrbach
(MFR) that have been used as herbal medicines in China and Korea. AJN and MFR have …

Natural products have shown potential to be combined with current cancer therapies to
improve patient outcomes. Nobiletin (NBT) is a citrus polymethoxyflavone and has been …

NF-κB signaling pathway is one of more thorough research to the signaling known, involved
in almost all of the tumorigenesis processes, including cell proliferation, apoptosis …

Background Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of
death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential …

A major current challenge in the treatment of advanced prostate cancer, which can be
initially controlled by medical or surgical castration, is the development of effective, safe, and …