Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at
advanced stages, with immediate requirement of new and effective treatment options …

Background Pancreatic cancer is one of the most lethal diseases with an incidence almost
equal to the mortality. In addition to having genetic causes, cancer can also be considered …

Pancreatic cancer (PC) is an aggressive disease characterized by high mortality. Diagnosis
at advanced stage, resistance, and recurrence are major hurdles for PC therapy and …

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late
diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal …

Over the past decades, the aberrant epigenetic modification, apart from genetic alteration,
has emerged as dispensable events mediating the transformation of pancreatic cancer (PC) …

The past several years have witnessed an explosive increase in our knowledge about
epigenetic features in human cancers. It has become apparent that pancreatic cancer is an …

Pancreatic cancer is one of the most aggressive human cancer types with a five-year
survival less than 7%. Emerging evidence revealed that many genetic alterations in …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

Background Chronic pancreatitis presents a high risk of inflammation-related progression to
pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death …

The reversibility of epigenetic landscapes, which are associated with pancreatic cancer
phenotypes, harbors a great potential for epigenetic reprogramming as a new therapeutic …