Analysis of vitamin D metabolic markers by mass spectrometry: Recent progress regarding the “gold standard” method and integration into clinical practice

A Alexandridou, P Schorr, CS Stokes… - Mass Spectrometry …, 2023 - Wiley Online Library
Liquid chromatography/tandem mass spectrometry is firmly established today as the gold
standard technique for analysis of vitamin D, both for vitamin D status assessments as well …

Analysis of vitamin D metabolic markers by mass spectrometry: current techniques, limitations of the “gold standard” method, and anticipated future directions

DA Volmer, LRBC Mendes… - Mass spectrometry …, 2015 - Wiley Online Library
Vitamin D compounds belong to a group of secosteroids, which occur naturally as vitamin
D3 in mammals and D2 in plants. Vitamin D is vital for bone health but recent studies have …

Vitamin D and metabolites measurement by tandem mass spectrometry

JMW van den Ouweland, M Vogeser… - Reviews in Endocrine and …, 2013 - Springer
The prevalence of vitamin D deficiency in the general population has become a major public
health problem. Vitamin D deficiency might have significant consequences not only to bone …

[HTML][HTML] Measurement of vitamin D metabolites by mass spectrometry, an analytical challenge

S Zelzer, W Goessler… - Journal of Laboratory and …, 2018 - jlpm.amegroups.org
Liquid-chromatography-tandem-mass-spectrometry (LC-MS/MS) is considered the gold
standard for the measurement of vitamin D metabolites as it does not suffer from most of the …

Analysis of vitamin D metabolites by liquid chromatography-tandem mass spectrometry

JMW van den Ouweland - TrAC Trends in Analytical Chemistry, 2016 - Elsevier
Measurement of vitamin D has increased significantly over the last years due to its
involvement not only in calcium homeostasis, but also in the pathogenesis of various …

Mass spectrometric profiling of vitamin D metabolites beyond 25-hydroxyvitamin D

MJ Müller, DA Volmer - Clinical chemistry, 2015 - academic.oup.com
BACKGROUND The frequency of measurements of vitamin D in the human population has
significantly increased over the last decade because vitamin D has now been linked to many …

Analysis and quantification of vitamin D metabolites in serum by ultra‐performance liquid chromatography coupled to tandem mass spectrometry and high‐resolution …

SJ Bruce, B Rochat, A Béguin, B Pesse… - Rapid …, 2013 - Wiley Online Library
RATIONALE The aim of the work was to develop and validate a method for the quantification
of vitamin D metabolites in serum using ultra‐high‐pressure liquid chromatography coupled …

Sample preparation techniques for extraction of vitamin D metabolites from non-conventional biological sample matrices prior to LC–MS/MS analysis

A Alexandridou, DA Volmer - Analytical and Bioanalytical Chemistry, 2022 - Springer
The determination of vitamin D metabolites as status marker or for diagnostic purposes is
almost entirely conducted from blood serum or plasma. Other biological matrices, however …

Approaches to measurement of vitamin D concentrations–mass spectrometry

U Kobold - Scandinavian Journal of Clinical and Laboratory …, 2012 - Taylor & Francis
Mass spectrometry today is the only analytical technology which allows the specific
determination of all known vitamin D metabolites. During the last few years the number of …

Metabolic profiling of major vitamin D metabolites using Diels–Alder derivatization and ultra-performance liquid chromatography–tandem mass spectrometry

PA Aronov, LM Hall, K Dettmer, CB Stephensen… - Analytical and …, 2008 - Springer
Biologically active forms of vitamin D are important analytical targets in both research and
clinical practice. The current technology is such that each of the vitamin D metabolites is …