The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …

ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …

The emergence of metallo-β-lactamases (MBLs) confers resistance to nearly all the β-lactam
antibiotics, including carbapenems. Currently, there is a lack of clinically useful MBL …

Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze and
inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute> 50 …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …

The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

After more than 80 years of development, β‐lactam drugs have become the most widely
used high‐efficiency, low‐toxic broad‐spectrum antibacterial drugs. However, with the …