Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

Proteomics and metabolomics investigations of body fluids present several challenges for
biomarker discovery of several diseases. The search for biomarkers is actually conducted in …

In the field of predictive, preventive and personalised medicine, researchers are keen to
identify novel and reliable ways to predict and diagnose disease, as well as to monitor …

The thin layer of tears covering the ocular surface are a complex body fluid containing
thousands of molecules of varied form and function of several origins. In this review, we …

The tear film is a layer of body fluid that maintains the homeostasis of the ocular surface. The
superior accessibility of tears and the presence of a high concentration of functional proteins …

The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …

The proteins found in tears have an important role in the maintenance of the ocular surface
and changes in the quality and quantity of tear components reflect changes in the health of …

Tears are a complex biological mixture containing electrolytes, metabolites, lipids, mucins,
some small organic molecules, and proteins. The tear film has various roles in the …

The tears, a critical body fluid of the surface of the eye, contain an unknown number of
molecules including proteins/peptides, lipids, small molecule metabolites, and electrolytes …

Considering absence of invasiveness and side effects, tears emerge as a particularly
attractive fluid for biomarker discovery and therefore for daily clinical use. However, to date …