Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

As the primary causes of myocardial infarction, stroke, atherosclerosis, in-stent restenosis,
and aneurysm, aortic diseases pose a serious threat to human health. Arterial remodeling is …

Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not
only play a key role in maintaining vascular structure but also perform various functions …

Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular
development. These cells perform biosynthetic, proliferative, and contractile roles in the …

The formation of vascular lesions is invariably associ-ated with the accumulation of
mesenchymal cells and their products in the intima, which either compromise the vessel …

In contrast with the heart, the adult mammalian vasculature retains significant remodelling
capacity, dysregulation of which is implicated in disease development. In particular, vascular …

Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to
neointimal thickening during spontaneous atherosclerosis and vessel renarrowing …

Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually
exposed to mechanical signals and biochemical components generated in the blood …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …