Performance verification of CYP2C19 enzyme abundance polymorphism settings within the simcyp simulator v21
C Sychterz, I Gardner, M Chiang, R Rachumallu… - Metabolites, 2022 - mdpi.com
Physiologically based pharmacokinetic (PBPK) modeling has a number of applications,
including assessing drug–drug interactions (DDIs) in polymorphic populations, and should …
including assessing drug–drug interactions (DDIs) in polymorphic populations, and should …
Prediction of inter-individual variability in the pharmacokinetics of CYP2C19 substrates in humans
K Chiba, K Shimizu, M Kato, T Nishibayashi… - Drug metabolism and …, 2014 - Elsevier
Significant inter-individual variability of exposure for CYP2C19 substrates may be only partly
due to genetic polymorphism. Therefore, the in vivo inter-individual variability in hepatic …
due to genetic polymorphism. Therefore, the in vivo inter-individual variability in hepatic …
Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes
Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme
and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment …
and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment …
Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism‐based adverse events
CL Shaffer, RJ Scialis, H Rong… - … & drug disposition, 2012 - Wiley Online Library
ABSTRACT Positive allosteric modulators ('potentiators') of the α‐amino‐3‐hydroxy‐5‐
methyl‐4‐isoxazolepropionic acid receptor (AMPAR) have been shown to display a …
methyl‐4‐isoxazolepropionic acid receptor (AMPAR) have been shown to display a …
Omeprazole limited sampling strategies to predict area under the concentration–time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping
EB Lawson, JC Wu, RM Baldwin… - European journal of …, 2012 - Springer
Purpose To develop a limited sampling strategy (LSS) to predict area under the
concentration–time curve (AUC) ratios of omeprazole (AUC OPZ) to its metabolites 5 …
concentration–time curve (AUC) ratios of omeprazole (AUC OPZ) to its metabolites 5 …
Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort
TM Dodgen, BI Drögemöller, GEB Wright… - …, 2015 - Future Medicine
Aim: To align predicted and measured CYP2C19 phenotype in a South African cohort.
Materials & methods: Genotyping of CYP2C19* 2,* 3,* 9,* 15,* 17,* 27 and* 28 was …
Materials & methods: Genotyping of CYP2C19* 2,* 3,* 9,* 15,* 17,* 27 and* 28 was …
Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole
T Frederiksen, J Areberg, A Raoufinia… - Clinical …, 2023 - Wiley Online Library
Accurate prediction of CYP2D6 phenotype from genotype information is important to support
safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate …
safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate …
Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes
S Hozuki, H Yoshioka, S Asano, M Nakamura… - Clinical …, 2023 - Springer
Background Mechanistic static pharmacokinetic (MSPK) models are simple, have fewer data
requirements, and have broader applicability; however, they cannot use in vitro information …
requirements, and have broader applicability; however, they cannot use in vitro information …
Evaluating a physiologically based pharmacokinetic model for prediction of omeprazole clearance and assessing ethnic sensitivity in CYP2C19 metabolic pathway
S Feng, Y Cleary, N Parrott, P Hu, C Weber… - European Journal of …, 2015 - Springer
Purpose The purpose of this study is to evaluate the ethnicity-specific population models in
the SimCYP Simulator® for prediction of omeprazole clearance with attention to differences …
the SimCYP Simulator® for prediction of omeprazole clearance with attention to differences …
Prediction of in vivo clearance and associated variability of CYP2C19 substrates by genotypes in populations utilizing a pharmacogenetics-based mechanistic model
It is important to examine the cytochrome P450 2C19 (CYP2C19) genetic contribution to
drug disposition and responses of CYP2C19 substrates during drug development. Design of …
drug disposition and responses of CYP2C19 substrates during drug development. Design of …