Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge,,,–
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …

Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of
hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …

Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Human microbiome studies have revealed the intricate interplay of host immunity and
bacterial communities to achieve homeostatic balance. Healthy skin microbial communities …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …

Infections can lead to persistent or long-term symptoms and diseases such as shingles after
varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal …

The COVID-19 pandemic continues to pose a major public health threat, especially in
countries with low vaccination rates. To better understand the biological underpinnings of …

The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …