Pulmonary epithelial cells act as the first line of defense against various air pollutant
particles. Previous studies have reported that particulate matter 2.5 (PM2. 5) could trigger …

Aims The senescence of alveolar epithelial type 2 (AT2) cells is implicated in the
pathogenesis of idiopathic pulmonary fibrosis (IPF). Cigarette smoke (CS) is a strong risk …

Abstract Particulate matter 2.5 (PM2. 5) is a widely known atmospheric pollutant which can
induce the aging-related pulmonary diseases such as acute respiratory distress syndrome …

Determining the mechanism of senescence‐associated pulmonary fibrosis is crucial for
designing more effective treatments for chronic lung diseases. This study aimed to …

OBJECTIVE: Chronic inflammation and cellular senescence are intertwined in the
pathogenesis of premature aging, which is considered as an important contributing factor in …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

Alveolar epithelial cell (AEC) mitochondrial (mt) DNA damage and fibrotic monocyte-derived
alveolar macrophages (Mo-AMs) are implicated in the pathobiology of pulmonary fibrosis …

Mitochondrial damage in airway epithelial cells plays an important role in the pathogenesis
of chronic obstructive pulmonary disease (COPD). Sirtuin 3 (Sirt3) is a mitochondrial …

Oxidative stress leads to alveolar epithelial cell injury and fibroblast–myofibroblast
differentiation (FMD), key events in the pathobiology of pulmonary fibrosis (PF). Sirtuin 3 …

Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and
contributes to heart failure with preserved ejection fraction (HFpEF). Our previous studies …