Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

INTRODUCTION Exercise provides a vast array of health benefits. The increased metabolic
activity of contracting skeletal muscle elicits an integrated response involving multiple …

Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex roles in inflammation and
metabolic disease. While typically regarded as a pro‐inflammatory cytokine, multiple studies …

Highlights•IL-6 is released into the circulation during exercise.•Exercise training reduces
visceral adipose tissue mass and this effect of exercise is abolished in the presence of IL-6 …

Circulating concentrations of canonically pro‐and anti‐inflammatory cytokines are
commonly measured when evaluating the anti‐inflammatory effects of exercise. An …

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of
immune responses. However, its mechanisms of action remain poorly understood. Here, we …

The lack of physical activity and overnutrition in our modern lifestyle culminates in what we
now experience as the current obesity and diabetes pandemic. Medical research performed …

Obesity and resistance to insulin are closely associated with the development of low-grade
inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its …

Derangements in whole body glucose and lipid metabolism, accompanied by insulin
resistance, are key features of obesity and the metabolic syndrome. A role for inflammation …

Summary Interleukin‐6 (IL‐6) is a central player in the regulation of inflammation,
haematopoiesis, immune response and host defense mechanisms. During the last decade …