Quantitative analysis of the vascular network anatomy is critical for the understanding of the
vasculature structure and function. In this study, we have combined microcomputed …

Rationale: A growing body of evidence supports the hypothesis that the Wnt/planar cell
polarity (PCP) pathway regulates endothelial cell proliferation and angiogenesis, but the …

Abstract Development and stabilization of a vascular plexus requires the coordination of
multiple signalling processes. Wnt planar cell polarity (PCP) signalling is critical in …

Aims Vascular permeability is essential for the health of normal tissues and is an important
characteristic of many disease states. The role of the Wnt/frizzled pathway in vascular …

The Wnt/β-catenin pathway is evolutionary conserved signaling system that regulates cell
differentiation and organogenesis. We show that endothelial specific stabilization of Wnt/β …

Objective—Vessel formation requires precise orchestration of a series of morphometric and
molecular events controlled by a multitude of angiogenic factors and morphogens …

Angiogenesis involves the coordinated growth and migration of endothelial cells (ECs)
toward a proangiogenic signal. The Wnt planar cell polarity (PCP) pathway, through the …

Blood vessel development requires orchestrated activities of heterogeneous endothelial cell
(EC) populations to create a hierarchically branched tubular network. Endothelial …

The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular
blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons …

Consistent with findings of Wnt pathway members involved in vascular cells, a role for
Wnt/Frizzled signaling has recently emerged in vascular cell development. Among the few …