Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …

In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …

Motivation The composition and density of immune cells in the tumor microenvironment
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …

RNA sequencing (RNA-seq) provides an efficient high-throughput technique to robustly
characterize the tumor immune microenvironment (TME). The increasing use of RNA-seq in …

Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of
heterogeneous tumour cells along with neighbouring stromal and immune cells. Here we …

Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form
ecosystems that determine disease progression and response to therapy. To characterize …

T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …