Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Substrate utilization by brown adipose tissue: what's hot and what's not?

BT McNeill, NM Morton, RH Stimson - Frontiers in endocrinology, 2020 - frontiersin.org
Our understanding of brown adipose tissue (BAT) function in humans has increased rapidly
over the past 10 years. This is predominantly due to the development of powerful non …

[HTML][HTML] Brown adipose tissue and thermogenesis

A Fenzl, FW Kiefer - Hormone molecular biology and clinical …, 2014 - degruyter.com
The growing understanding of adipose tissue as an important endocrine organ with multiple
metabolic functions has directed the attention to the (patho) physiology of distinct fat depots …

Brown adipose tissue energy metabolism in humans

AC Carpentier, DP Blondin, KA Virtanen… - Frontiers in …, 2018 - frontiersin.org
The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Energy dissipation in brown adipose tissue: from mice to men

MJ Vosselman, WD van Marken Lichtenbelt… - Molecular and cellular …, 2013 - Elsevier
In rodents, brown adipose tissue (BAT) is a metabolic organ that produces heat in response
to cold and dietary intake through mitochondrial uncoupling. For long time, BAT was …

Mechanisms of impaired brown adipose tissue recruitment in obesity

M Alcalá, M Calderon-Dominguez, D Serra… - Frontiers in …, 2019 - frontiersin.org
Brown adipose tissue (BAT) dissipates energy to produce heat. Thus, it has the potential to
regulate body temperature by thermogenesis. For the last decade, BAT has been in the …

Brown adipocyte glucose metabolism: a heated subject

MK Hankir, M Klingenspor - EMBO reports, 2018 - embopress.org
The energy expending and glucose sink properties of brown adipose tissue (BAT) make it
an attractive target for new obesity and diabetes treatments. Despite decades of research …

Brown fat fuel utilization and thermogenesis

KL Townsend, YH Tseng - Trends in Endocrinology & Metabolism, 2014 - cell.com
Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis
and to contribute to energy expenditure in rodents and possibly humans. The energetic …

Human brown adipose tissue as a target for obesity management; beyond cold‐induced thermogenesis

RKC Loh, BA Kingwell, AL Carey - Obesity reviews, 2017 - Wiley Online Library
Elevating energy expenditure via adaptive thermogenesis in brown adipose tissue (BAT) is
a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on …

An endocrine role for brown adipose tissue?

J Villarroya, R Cereijo… - American journal of …, 2013 - journals.physiology.org
White adipose tissue is recognized as both a site of energy storage and an endocrine organ
that produces a myriad of endocrine factors called adipokines. Brown adipose tissue (BAT) …