eXplainable Artificial Intelligence (XAI) in aging clock models

A Kalyakulina, I Yusipov, A Moskalev… - Ageing Research …, 2023 - Elsevier
XAI is a rapidly progressing field of machine learning, aiming to unravel the predictions of
complex models. XAI is especially required in sensitive applications, eg in health care, when …

An explainable AI framework for interpretable biological age

W Qiu, H Chen, M Kaeberlein, SI Lee - medRxiv, 2022 - medrxiv.org
Background An individual's biological age is a measurement of health status and provides a
mechanistic understanding of aging. Age clocks estimate a biological age of an individual …

[HTML][HTML] Towards AI-driven longevity research: an overview

N Marino, G Putignano, S Cappilli, E Chersoni… - Frontiers in …, 2023 - frontiersin.org
While in the past technology has mostly been utilized to store information about the
structural configuration of proteins and molecules for research and medical purposes …

[HTML][HTML] ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age

W Qiu, H Chen, M Kaeberlein, SI Lee - The Lancet Healthy Longevity, 2023 - thelancet.com
Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

[HTML][HTML] Artificial intelligence for aging and longevity research: Recent advances and perspectives

A Zhavoronkov, P Mamoshina, Q Vanhaelen… - Ageing research …, 2019 - Elsevier
The applications of modern artificial intelligence (AI) algorithms within the field of aging
research offer tremendous opportunities. Aging is an almost universal unifying feature …

[HTML][HTML] Modeling transcriptomic age using knowledge-primed artificial neural networks

N Holzscheck, C Falckenhayn, J Söhle… - npj Aging and …, 2021 - nature.com
The development of 'age clocks', machine learning models predicting age from biological
data, has been a major milestone in the search for reliable markers of biological age and …

[HTML][HTML] Deep aging clocks: the emergence of AI-based biomarkers of aging and longevity

A Zhavoronkov, P Mamoshina - Trends in Pharmacological Sciences, 2019 - cell.com
First published in 2016, predictors of chronological and biological age developed using
deep learning (DL) are rapidly gaining popularity in the aging research community. These …

Application of AI in biological age prediction

D Meng, S Zhang, Y Huang, K Mao, JDJ Han - Current Opinion in Structural …, 2024 - Elsevier
The development of anti-aging interventions requires quantitative measurement of biological
age. Machine learning models, known as “aging clocks,” are built by leveraging diverse …

Explainable machine learning framework to predict personalized physiological aging

D Bernard, E Doumard, I Ader, P Kemoun, J Pagès… - Aging cell, 2023 - Wiley Online Library
Attaining personalized healthy aging requires accurate monitoring of physiological changes
and identifying subclinical markers that predict accelerated or delayed aging. Classic …

Artificial intelligence in longevity medicine

A Zhavoronkov, E Bischof, KF Lee - Nature Aging, 2021 - nature.com
Recent advances in deep learning enabled the development of AI systems that outperform
humans in many tasks and have started to empower scientists and physicians with new …