COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

WS Ho, R Zhang, YL Tan, CLL Chai - Pharmacological Research, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a
standstill. As the disease continues to rage two years on, it is apparent that effective …

Recent advances in small-molecular therapeutics for COVID-19

L Zhong, Z Zhao, X Peng, J Zou… - Precision Clinical …, 2022 - academic.oup.com
The COVID-19 pandemic poses a fundamental challenge to global health. Since the
outbreak of SARS-CoV-2, great efforts have been made to identify antiviral strategies and …

The need for speed and efficiency: a brief review of small molecule antivirals for COVID-19

AC Puhl, TR Lane, F Urbina, S Ekins - Frontiers in Drug Discovery, 2022 - frontiersin.org
While we currently have multiple highly effective vaccines approved for use against SARS-
CoV-2 in the USA and other countries, there are far fewer small molecule antivirals …

Races of small molecule clinical trials for the treatment of COVID‐19: an up‐to‐date comprehensive review

S Hu, S Jiang, X Qi, R Bai, XY Ye… - Drug Development …, 2022 - Wiley Online Library
Abstract The coronavirus disease‐19 (COVID‐19) pandemic has become a global threat
since its first outbreak at the end of 2019. Several review articles have been published …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal Transduction and Targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

[HTML][HTML] Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review

L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …

What will be the role of molnupiravir in the treatment of COVID-19 infection?

A Vitiello, V Troiano, R La Porta - Drugs & Therapy Perspectives, 2021 - Springer
The global COVID-19 pandemic is currently underway. To date, there are approximately
4.55 million deaths and 219 million people infected [1]. The massive vaccination campaign …

Small-molecule antiviral agents in ongoing clinical trials for COVID-19

ÇB Apaydın, G Çınar, G Cihan-Üstündağ - Current drug targets, 2021 - ingentaconnect.com
The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in December 2019 and has …

Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

S Khiali, E Khani, SB Rouy… - Future Microbiology, 2022 - Future Medicine
Despite the progress in the management of COVID-19, effective oral antiviral agents are still
lacking. In the present review, the potential beneficial effects of molnupiravir in the …

Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors

A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2023 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …