[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

D Basavarajappa, C Galindo-Romero, V Gupta… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …

Regulated cell death of retinal ganglion cells in glaucoma: molecular insights and therapeutic potentials

W Zhao, C Fan, X Hu, X Ban, H Wan, Y He… - Cellular and Molecular …, 2023 - Springer
Glaucoma is a group of diseases characterized by the degeneration of retinal ganglion cells
(RGCs) and progressive, irreversible vision loss. High intraocular pressure (IOP) heightens …

Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage

JA Fernández-Albarral, AI Ramírez… - Frontiers in Cellular …, 2024 - frontiersin.org
Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss
of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of …

Mechanisms of retinal ganglion cell injury and defense in glaucoma

J Qu, D Wang, CL Grosskreutz - Experimental eye research, 2010 - Elsevier
Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to
blindness. Over the past decade and a half, information has begun to emerge regarding …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection

MB Wax, G Tezel - Molecular neurobiology, 2002 - Springer
Although glaucomatous optic nerve degeneration is a leading cause of worldwide
blindness, neither the precise cellular mechanisms underlying neurodegeneration in …

A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma

G Tezel - Progress in Brain Research, 2020 - Elsevier
Glaucoma is a complex neurodegenerative disease involving RGC axons, somas, and
synapses at dendrites and axon terminals. Recent research advancements in the field have …

Molecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection

Y Munemasa, Y Kitaoka - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Glaucoma, which affects more than 70 million people worldwide, is a heterogeneous group
of disorders with a resultant common denominator; optic neuropathy, eventually leading to …

Molecular pathways in experimental glaucoma models

K Bugara, A Pacwa, A Smedowski - Frontiers in Neuroscience, 2024 - frontiersin.org
Glaucoma is a complex and progressive disease that primarily affects the optic nerve axons,
leading to irreversible vision loss. Although the exact molecular mechanisms underlying …

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy

RW Nickells, GR Howell, I Soto… - Annual review of …, 2012 - annualreviews.org
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …