Associations between maternal lifetime stressors and negative events in pregnancy and breast milk-derived extracellular vesicle microRNAs in the programming of …

AK Bozack, E Colicino, R Rodosthenous… - Epigenetics, 2021 - Taylor & Francis
Maternal stress is associated with adverse child health. Breast milk microRNAs
encapsulated in extracellular vesicles (EVs) are involved in mother-infant biochemical …

Breast milk-derived extracellular vesicle miRNAs are associated with maternal asthma and atopy

AK Bozack, E Colicino, RS Rodosthenous… - …, 2022 - Taylor & Francis
Background: Breast milk-derived extracellular vesicle (EV) miRNAs may program child
health outcomes associated with maternal asthma and atopy. The authors investigated …

Depression, perceived stress, and distress during pregnancy and EV-associated miRNA profiles in MADRES

HB Foley, CG Howe, SP Eckel, T Chavez… - Journal of affective …, 2023 - Elsevier
Background MicroRNA (miRNA) circulating in plasma has been proposed as biomarkers for
a variety of diseases and stress measures, including depression, stress, and trauma …

Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands

A Kupsco, D Prada, D Valvi, L Hu, MS Petersen… - Scientific reports, 2021 - nature.com
Human milk plays a critical role in infant development and health, particularly in cognitive,
immune, and cardiometabolic functions. Milk contains extracellular vesicles (EVs) that can …

Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring

FCR Zucchi, Y Yao, ID Ward, Y Ilnytskyy, DM Olson… - PloS one, 2013 - journals.plos.org
The gestational state is a period of particular vulnerability to diseases that affect maternal
and fetal health. Stress during gestation may represent a powerful influence on maternal …

Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study

CG Howe, HB Foley, EM Kennedy, SP Eckel… - Epigenetics, 2022 - Taylor & Francis
Circulating miRNA may contribute to the development of adverse birth outcomes. However,
few studies have investigated extracellular vesicle (EV) miRNA, which play important roles …

Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort

HB Foley, CG Howe, SP Eckel, T Chavez, L Gevorkian… - PloS one, 2021 - journals.plos.org
MicroRNA (miRNA) circulating in plasma have been proposed as biomarkers for a variety of
conditions and diseases, including complications during pregnancy. During pregnancy …

Ancestral experience as a game changer in stress vulnerability and disease outcomes

GAS Metz, JWY Ng, I Kovalchuk, DM Olson - Bioessays, 2015 - Wiley Online Library
Stress is one of the most powerful experiences to influence health and disease. Through
epigenetic mechanisms, stress may generate a footprint that propagates to subsequent …

Gestational diabetes mellitus is associated with altered abundance of exosomal MicroRNAs in human milk

KB Shah, DA Fields, NP Pezant, HK Kharoud… - Clinical …, 2022 - Elsevier
Purpose Human milk (HM) is a unique biological fluid that is enriched with a variety of
factors, including microRNAs (miRNAs) that potentially provide both short-and long-term …

First trimester PBMC microRNA predicts adverse pregnancy outcome

EE Winger, JL Reed, X Ji - American journal of reproductive …, 2014 - Wiley Online Library
Problem Prior to the end of the first trimester, pathogenic mechanisms may commit
pregnancies to adverse outcome such as pre‐eclampsia and miscarriage. A long‐term …