Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …

OBJECTIVE: To review the effect of increasing age on the immune system and some of its
clinical implications. DATA SOURCES: MEDLINE and PubMed searches were performed …

Abstract On April 7, 8, 2009 a Symposium entitled" Pathophysiology of Successful and
Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Immunosenescence is the consequence of the continuous attrition caused by chronic
antigenic stress. The most important characteristics of immunosenescence (accumulation of …

Immunosenescence is an age-associated decline of immunity involving multiorgan changes.
As the mean age of the population increases, an increase of diverse pathologies associated …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Nowadays, it is well known that with advancing age individuals are at an increased
susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …