Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …

Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Understanding the normal state of human tissue transcriptome profiles is essential for
recognizing tissue disease states and identifying disease markers. Recently, the Human …

The cumulative activity of all of the body's cells, with their myriad interactions, life histories,
and environmental experiences, gives rise to a condition that is distinctly human and specific …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …

Single-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in
complex tissues that are challenging to dissociate or are frozen, and opens the way to …

Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …