It remains an open question when and how the first cell fate decision is made in mammals.
Using deep single-cell RNA-seq of matched sister blastomeres, we report highly …

During mammalian pre-implantation embryo development, when the first asymmetry
emerges and how it develops to direct distinct cell fates remain longstanding questions …

The formation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the
earliest events during mammalian embryogenesis. It is believed that the orientation of …

INTRODUCTION Metazoan development represents a big jump in complexity compared
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Expression from both alleles is generally observed in analyses of diploid cell populations,
but studies addressing allelic expression patterns genome-wide in single cells are lacking …

Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

The first cell lineage specification in mouse embryo development is the formation of
trophectoderm (TE) and inner cell mass (ICM) of the blastocyst. This article is to review and …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

In recent years, genome-wide profiling approaches have begun to uncover the molecular
programs that drive developmental processes. In particular, technical advances that enable …