The neurodevelopmental model of schizophrenia, which posits that the illness is the end
state of abnormal neurodevelopmental processes that started years before the illness onset …

The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Neurodevelopmental models of schizophrenia that identify longitudinal precursors of illness
have been of great heuristic importance focusing most etiologic research over the past two …

Since a proposal in 1986 that schizophrenia involved early neurodevelopmental deviations
beginning in intrauterine life that showed varying expressivity as relevant neural systems …

The neurodevelopmental hypothesis of schizophrenia suggests that the disruption of early
brain development increases the risk of later developing schizophrenia. This hypothesis …

Over a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-
derived neural models has provided substantial data describing neurobiological …

The schizophrenia brain is differentiated from the normal brain by subtle changes, with
significant overlap in measures between normal and disease states. For the past 25 years …

To account for the complex genetics, the developmental biology, and the late
adolescent/early adulthood onset of schizophrenia, the “two-hit” hypothesis has gained …

Objective Neurodevelopmental disorders presumably involve events that occur during brain
development. The authors hypothesized that neuropsychiatric disorders considered to be …