In this review, we explore systemization of knowledge about the triggering effects of non-
genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid …

Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that affects 0.5–1% of
the population. RA causes progressive joint destruction that leads to the restriction of …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

The etiopathogenesis of rheumatoid arthritis (RA) is partially understood. Genetic,
environmental, and hormonal factors and their interactions are considered to play an …

There is now a general consensus that RA has a spectrum of disease stages that can begin
many years before the onset of clinical symptoms. It is widely thought that understanding the …

Rheumatoid arthritis (RA) is an autoimmune disorder with a number of risk factors, including
both genetic and environmental. A number of RA risk associated genomic loci has been …

A desire to cure and even prevent RA has led to an increased interest in its earliest phases—
those clinically apparent phases of disease before patients have developed the full set of …

The association of rheumatoid arthritis (RA) with a number of genetic risk loci is well
established; however, only part of the risk to develop the disease is based on genetics …

Multiple environmental factors including hormones, dietary factors, infections, and exposure
to tobacco smoke, as well as gene-environment interactions, have been associated with …

Objective We developed rheumatoid arthritis (RA) risk models based on validated
environmental factors (E), genetic risk scores (GRS), and gene–environment interactions …