Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells
JH Lee, L Toy, JT Kos, Y Safonova, WR Schief… - NPJ vaccines, 2021 - nature.com
A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome
the hurdle of being able to activate naive precursor B cells encoding features within their …
the hurdle of being able to activate naive precursor B cells encoding features within their …
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
Animal models of human antigen-specific B cell receptors (BCRs) generally depend on
“inferred germline” sequences, and thus their relationship to authentic naive human B cell …
“inferred germline” sequences, and thus their relationship to authentic naive human B cell …
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Traditional vaccine development to prevent some of the worst current pandemic diseases
has been unsuccessful so far. Germline-targeting immunogens have potential to prime …
has been unsuccessful so far. Germline-targeting immunogens have potential to prime …
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity
P Dosenovic, EE Kara, AK Pettersson… - Proceedings of the …, 2018 - National Acad Sciences
The discovery that humans can produce potent broadly neutralizing antibodies (bNAbs) to
several different epitopes on the HIV-1 spike has reinvigorated efforts to develop an …
several different epitopes on the HIV-1 spike has reinvigorated efforts to develop an …
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates
JM Steichen, I Phung, E Salcedo, G Ozorowski… - Science, 2024 - science.org
Germline-targeting immunogens hold promise for initiating the induction of broadly
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
INTRODUCTION A major goal of HIV-1 vaccine development is the design of immunogens
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
INTRODUCTION HIV newly infects 1.8 million people each year, making development of an
HIV vaccine a global health priority. Nearly all licensed vaccines protect by inducing …
HIV vaccine a global health priority. Nearly all licensed vaccines protect by inducing …