ABSTRACT Three‐dimensional (3D) cell culture models are becoming increasingly popular
in contemporary cancer research and drug resistance studies. Recently, scientists have …

Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …

Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …

In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Introduction The high failure rate in drug discovery remains a costly and time-consuming
challenge. Improving the odds of success in the early steps of drug development requires …

High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …

Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …

Simple Summary Cancer cell lines, grown on plastic dishes ie, two-dimensional (2D), are
routinely used in cancer research, eg, when evaluating the effectiveness of potential anti …

Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …