We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

To reconstruct modern human evolutionary history and identify loci that have shaped hunter-
gatherer adaptation, we sequenced the whole genomes of five individuals in each of three …

Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

African Pygmies practicing a mobile hunter-gatherer lifestyle are phenotypically and
genetically diverged from other anatomically modern humans, and they likely experienced …

Comparison of protein-coding DNA sequences from diverse primates can provide insight
into these species' evolutionary history and uncover the molecular basis for their phenotypic …

The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

African Pygmy groups show a distinctive pattern of phenotypic variation, including short
stature, which is thought to reflect past adaptation to a tropical environment. Here, we …

Abstract The southern African indigenous Khoe-San populations harbor the most divergent
lineages of all living peoples. Exploring their genomes is key to understanding deep human …

We explored ancestry-related differences in the genetic architecture of whole-blood gene
expression using whole-genome and RNA sequencing data from 2,733 African Americans …

Abstract The Southern African Human Genome Programme is a national initiative that
aspires to unlock the unique genetic character of southern African populations for a better …