Pancreatic cancer is considered as one of the most lethal types of cancer due to its poor
prognosis and lack of effective therapeutic approaches. Although many studies have been …

Inflammation involves interactions between various immune cells, inflammatory cells,
chemokines and cytokines in pancreatic cancer. Cancer cells as well as surrounding stromal …

The interactions between tumor immune microenvironment (TIME) and pancreatic cancer
cells can affect chemotherapeutic efficacy; however, the mechanisms still remain largely …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer
with poor prognosis. Despite extensive efforts, the current treatment methods have limited …

The tumor microenvironment is replete with cells that evolve with and provide support to
tumor cells during the transition to malignancy. The hijacking of the immune system in the …

Pancreatic cancer (PC) is a fatal disease with high malignancy and difficult for early
diagnosis. PC causes more than 400,000 patient deaths world widely and becomes the …

Pancreatic cancer is a devastating disease with poor prognosis in the modern era.
Inflammatory processes have emerged as key mediators of pancreatic cancer development …

Background: Research over the last twenty years has yielded much insight into pancreatic
cancer biology, but it has neither improved diagnostics methods nor the way of treatment …

Objective: Tumor-associated macrophages (TAMs) deserve more focus because of its
pivotal role in the development of solid tumors and they are related to poor outcomes of …

Monocytes and macrophages make up part of the innate immune system and provide one of
the first defenses against variety of treats. Macrophages can also modulate the adaptive …