The porcine reproductive and respiratory syndrome virus nsp1 is predicted to be auto-
cleaved from the replicase polyprotein into nsp1α and nsp1β subunits. In infected cells, we …

There is growing evidence that porcine reproductive and respiratory syndrome virus
(PRRSV) has developed mechanisms to subvert the host innate immune response. PRRSV …

Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a
serious disease characterized by a delayed and defective adaptive immune response. It is …

Abstract Background Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that
plays a key role in inflammation and immune responses, as well as in the regulation of cell …

Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious
pathogen that causes severe diseases in pigs and great economic losses to the swine …

The objective of this study was to identify porcine reproductive and respiratory syndrome
virus (PRRSV)-encoded proteins that are responsible for the inhibition of TNF-α expression …

Non-structural protein (nsp) 1 of PRRS virus is a viral antagonist for type I interferons (IFNs),
and in cells expressing nsp1, CREB-binding protein (CBP) is degraded. nsp1 is auto …

Induction of type I interferon (IFN-α/β) is an early antiviral response of the host, and porcine
reproductive and respiratory syndrome virus (PRRSV) has been reported to downregulate …

Porcine reproductive and respiratory syndrome (PRRS) virus nonstructural protein 2 (nsp2)
contains a cysteine protease domain at its N terminus, which belongs to the ovarian tumor …

Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the interferon-
mediated antiviral response. Type I interferons (IFNs) induce the expression of IFN …