BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity
J Moreira, PMA Silva, E Castro, L Saraiva… - International Journal of …, 2024 - mdpi.com
Recently, the diarylpentanoid BP-M345 (5) has been identified as a potent in vitro growth
inhibitor of cancer cells, with a GI50 value between 0.17 and 0.45 µM, showing low toxicity in …
inhibitor of cancer cells, with a GI50 value between 0.17 and 0.45 µM, showing low toxicity in …
BP-M345, a new diarylpentanoid with promising antimitotic activity
P Novais, PMA Silva, J Moreira, A Palmeira, I Amorim… - Molecules, 2021 - mdpi.com
Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on
human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP …
human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP …
Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro
In the present study, a series of forty-five asymmetrical meta-methoxylated diarylpentanoids
have been synthesized, characterized and evaluated for their in-vitro anti-cancer potential …
have been synthesized, characterized and evaluated for their in-vitro anti-cancer potential …
Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer
In the present study, a series of nine stable 3, 4, 5-methoxylphenyl-containing asymmetrical
diarylpentanoids, derivatives of curcuminoids, have been synthesized, characterized and …
diarylpentanoids, derivatives of curcuminoids, have been synthesized, characterized and …
A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation
J Moreira, J Almeida, JB Loureiro, H Ramos… - …, 2021 - Wiley Online Library
In silico studies of a library of diarylpentanoids led us to the identification of potential new
MDM2/X ligands. The diarylpentanoids with the best docking scores obeying the …
MDM2/X ligands. The diarylpentanoids with the best docking scores obeying the …
Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization
J Moreira, JB Loureiro, D Correia, A Palmeira… - Pharmaceuticals, 2023 - mdpi.com
We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced
p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and …
p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and …
[PDF][PDF] Naturally occurring 1, 5-diarylpentanoids: a review
N Celebioglu, U Ozgen - Organic Communications, 2017 - acgpubs.org
Naturally Occurring 1,5-Diarylpentanoids: A Review Page 1 REVIEW ARTICLE The article was
published by ACG Publications www.acgpubs.org/OC/index.htm © October-December 2017 …
published by ACG Publications www.acgpubs.org/OC/index.htm © October-December 2017 …
Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships
J Moreira, L Saraiva, MM Pinto, H Cidade - Molecules, 2022 - mdpi.com
Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …
structurally related to chalcones, have gained increasing attention due to their wide array of …
In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against LoVo colorectal cancer cells
In the present study, we investigated the in-vitro anti-cancer potential of six diarylpentanoids
against a panel of BRAF-and KRAS-mutated colorectal cancer cell lines including T84 …
against a panel of BRAF-and KRAS-mutated colorectal cancer cell lines including T84 …
Anti-Cancer Mechanisms of Diarylpentanoid MS17 (1, 5-Bis (2-hydroxyphenyl)-1, 4-pentadiene-3-one) in Human Colon Cancer Cells: A Proteomics Approach
Diarylpentanoids are synthesized to overcome curcumin's poor bioavailability and low
stability to show enhanced anti-cancer effects. Little is known about the anti-cancer effects of …
stability to show enhanced anti-cancer effects. Little is known about the anti-cancer effects of …