The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Proteolytic ectodomain release, a process known as “shedding”, has been recognised as a
key mechanism for regulating the function of a diversity of cell surface proteins. A Disintegrin …

The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …

ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …

Proteolytic cleavage of transmembrane proteins is an important post-translational
modification that regulates the biological function of numerous transmembrane proteins …

The discovery of the disintegrin and metalloproteinase 17 (ADAM17), originally identified as
tumor necrosis factor-a converting enzyme (TACE) for its ability as sheddase of TNF-α …

While it is highly accepted that ADAM family members with ubiquitous expression patterns,
such as ADAM10 and ADAM17 have major roles in homoeostasis and pathology, ADAM8 …

Both cancer and chronic inflammatory diseases are often marked by homeostatic signal
transduction pathways run amok. Cleavage of membrane-bound substrates by extracellular …

ADAM15 is a widely expressed multi-domain protease that has been implicated in the
pathogenesis of many human diseases. Given the diversity of the ADAM15 functional …