Ceramides are a class of bioactive sphingolipids increasingly recognized in metabolic
disease, heart failure (HF), atherosclerosis, and cardiovascular death (1). Despite …

Background A higher circulating plasma ceramide ratio (C16: 0/C24: 0) is associated with an
increased risk of heart failure, even after accounting for standard risk factors including lipid …

Aims Ceramides exert several biological activities that may contribute to the
pathophysiology of cardiovascular disease and heart failure (HF). The association between …

Serum ceramides have emerged as potential biomarkers of insulin resistance, diabetes, and
heart disease. In this issue of Diabetes, Lemaitre et al.(1) report the largest longitudinal …

Background Ceramide is involved in apoptosis, inflammation, and stress responses, which
are among the pathogenic components of chronic heart failure (CHF). However, no one has …

Background: Ceramides exhibit multiple biological activities that may influence the
pathophysiology of heart failure. These activities may be influenced by the saturated fatty …

High cardiac levels of total ceramides are noted in heart failure. In the plasma, C16: 0/C24: 0
ceramides may be a valuable biomarker of preclinical left ventricular dysfunction …

Importance Sphingolipids, including ceramides and sphingomyelins, may influence the
pathophysiology and risk of sudden cardiac death (SCD) through multiple biological …

Serum lipids such as cholesterol and triglycerides, which are the most abundant lipids in the
circulation, are well-known biomarkers of risk of major adverse cardiac events. Recent …

Background Worsening heart failure (WHF) is a heterogeneous clinical syndrome with poor
prognosis. More effective risk stratification tools are required to identify high-risk patients …