Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer

LA Stecanella, APR Bitencourt, GR Vaz, E Quarta… - Pharmaceutics, 2021 - mdpi.com
Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the
plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti …

Glycyrrhetinic acid mediated drug delivery carriers for hepatocellular carcinoma therapy

Y Cai, Y Xu, HF Chan, X Fang, C He… - Molecular …, 2016 - ACS Publications
Glycyrrhetinic acid (GA), the main hydrolysate of glycyrrhizic acid extracted from the root of
licorice, has been used in hepatocellular carcinoma (HCC) therapy. Particularly, GA as a …

Exploring the pharmacological potential of glycyrrhizic acid: From therapeutic applications to trends in nanomedicine

MHM Nascimento, DR de Araújo - Future Pharmacology, 2022 - mdpi.com
Glycyrrhizic acid (GA) is the main active component of the licorice root, which has been
known in traditional medicine since the ancient times. It is a molecule composed of a …

Recent advances in glycyrrhetinic acid-functionalized biomaterials for liver cancer-targeting therapy

A Speciale, C Muscarà, MS Molonia, M Cristani… - Molecules, 2022 - mdpi.com
Liver cancer is one of the most common causes of cancer mortality worldwide.
Chemotherapy and radiotherapy are the conventional therapies generally employed in …

Glycyrrhizic acid as a multifunctional drug carrier–From physicochemical properties to biomedical applications: A modern insight on the ancient drug

OY Selyutina, NE Polyakov - International journal of pharmaceutics, 2019 - Elsevier
Glycyrrhizic acid is the main active component of Licorice root which has been known in
traditional Chinese and Japanese medicine since ancient times. In these cultures …

Glycyrrhetinic acid functionalized nanoparticles for drug delivery to liver cancer

F Wu, X Li, B Jiang, J Yan, Z Zhang… - Journal of …, 2018 - ingentaconnect.com
Liver cancer is one of the most common human malignancies worldwide. Currently,
chemotherapy remains the cornerstone for liver cancer treatment. However, chemotherapy …

Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs

L Zhang, J Yao, J Zhou, T Wang, Q Zhang - International Journal of …, 2013 - Elsevier
Glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate was synthesized as a carrier for
intravenous administration of paclitaxel (PTX), which combined hyaluronic acid (HA) and …

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

S JináKim, D HoonáKang, W YoungáKim… - Chemical …, 2018 - pubs.rsc.org
Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for
hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small …

Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery

Y Zu, L Meng, X Zhao, Y Ge, X Yu… - International Journal of …, 2013 - Taylor & Francis
Introduction The livertaxis of glycyrrhizic acid-conjugated bovine serum albumin (GL-BSA)
has been reported in the literature. Now, in this paper, we describe a novel type of drug …

Glycyrrhizic acid in the treatment of liver diseases: literature review

J Li, H Cao, P Liu, G Cheng… - BioMed research …, 2014 - Wiley Online Library
Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants
(Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and …