In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At
present, management options to prevent metastasis are limited and non-curative. In this …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high
potency to form lung metastases which is the main cause of death. Unfortunately, the …

Osteosarcoma (OS) is a devastating illness with rapid rates of dissemination and a poor
overall prognosis, despite aggressive standard-of-care surgical techniques and combination …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Osteosarcoma is an extremely genetically unstable tumor with multiple numerical and
structural chromosomal alterations. Chromothripsis and alternative lengthening of telomeres …

Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment
strategies target the primary tumour rather than metastases and have a limited efficacy in the …

Despite successful primary tumor treatment, the development of pulmonary metastasis
continues to be the most common cause of mortality in patients with osteosarcoma. A …

Simple Summary Osteosarcomas are heterogeneous bone tumors with complex genetic and
chromosomic alterations. The numerous patients with metastatic osteosarcoma have a very …

Background Osteosarcoma is a primary malignant tumor originating from mesenchymal
tissue, with a poor distant metastasis prognosis. The molecular mechanisms of …