Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

The neurotrophins are a family of proteins that are essential for the development of the
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …

Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell
surface receptors: members of the Trk-family receptor tyrosine kinases and p75 NTR, a …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the
fate of the neuron, not only during embryonic development, but also in the adult brain …

There is growing evidence that reduced neurotrophic support is a significant factor in the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …

The neurotrophins mediate diverse actions in the developing peripheral and central nervous
systems. They are initially synthesized as precursor forms, or proneurotrophins, that are …

Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction.
Recently, other roles for these receptors have been identified. Many questions have been …

Neurotrophins are growth factors that promote cell survival, differentiation, and cell death.
They are synthesized as proforms that can be cleaved intracellularly to release mature …