Biological role and regulation of circular RNA as an emerging biomarker and potential therapeutic target for cancer

A Saleem, MU Khan, T Zahid, I Khurram… - Molecular Biology …, 2024 - Springer
Circular RNAs (circRNAs) are a unique family of endogenous RNAs devoid of 3′ poly-A
tails and 5′ end caps. These single-stranded circRNAs, found in the cytoplasm, are …

Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential

NR DeSouza, KJ Nielsen, T Jarboe, M Carnazza… - Biomolecules, 2024 - mdpi.com
Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic
regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly …

[HTML][HTML] Circular RNAs in cancer

DH Bach, SK Lee, AK Sood - Molecular Therapy-Nucleic Acids, 2019 - cell.com
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are
formed by precursor mRNA back-splicing or skipping events of thousands of genes in …

The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Circular RNAs: insights into clinical and therapeutic approaches for various cancers

F Akram, N Nasir, FI Shah - Current Protein and Peptide …, 2023 - ingentaconnect.com
Background: With the advent of cancer diagnostics and therapeutics, circular RNAs
(circRNAs) are swiftly becoming one of the significant regulators of gene expression and …

Functional role of circular RNAs in cancer development and progression

WL Ng, TB Mohd Mohidin, K Shukla - RNA biology, 2018 - Taylor & Francis
Circular RNAs (circRNAs) are a large class of endogenously expressed non-coding RNAs
formed by covalently closed loops through back-splicing. High throughput sequencing …

New molecular mechanisms and clinical impact of circRNAs in human cancer

G Fontemaggi, C Turco, G Esposito, S Di Agostino - Cancers, 2021 - mdpi.com
Simple Summary Circular RNAs (circRNAs) belong to a new class of non-coding RNAs
implicated in cellular physiological functions but also in the evolution of various human …

Circular RNAs: emerging role in cancer diagnostics and therapeutics

A Rajappa, S Banerjee, V Sharma… - Frontiers in molecular …, 2020 - frontiersin.org
Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene
expression and cellular functions. They elicit their influence via a plethora of diverse …

The emerging functions and roles of circular RNAs in cancer

S Qu, Z Liu, X Yang, J Zhou, H Yu, R Zhang, H Li - Cancer letters, 2018 - Elsevier
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that
undergo a specific backsplicing from pre-mRNA. With the application of high-throughput …

Insights into the role of CircRNAs: biogenesis, characterization, functional, and clinical impact in human malignancies

S Nisar, AA Bhat, M Singh, T Karedath… - Frontiers in cell and …, 2021 - frontiersin.org
Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding
endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be …