Associations of Triglycerides and Atherogenic Index of Plasma with Brain Structure in the Middle-Aged and Elderly Adults

X Chen, Y Bao, J Zhao, Z Wang, Q Gao, M Ma, Z Xie… - Nutrients, 2024 - mdpi.com
Triglyceride (TG) and atherogenic index of plasma (AIP) have been acknowledged to be risk
factors for vascular insults, but their impacts on the brain system remain elusive. To fill in …

Is adiposity associated with white matter microstructural health and intelligence differently in males and females?

A Patel, JA Chad, JJ Chen - Obesity, 2023 - Wiley Online Library
Objective The role of vascular risk factors in age‐related brain degeneration has long been
the subject of intense study, but the role of obesity remains understudied. Given known sex …

[HTML][HTML] Association of mid-life serum lipid levels with late-life brain volumes: The atherosclerosis risk in communities neurocognitive study (ARICNCS)

K Moazzami, MC Power, R Gottesman, T Mosley… - Neuroimage, 2020 - Elsevier
Background Limited information exists regarding the association between midlife lipid levels
and late-life total and regional brain volumes. Methods We studied 1872 participants in the …

[HTML][HTML] Adverse associations between visceral adiposity, brain structure, and cognitive performance in healthy elderly

V Isaac, S Sim, H Zheng, V Zagorodnov… - Frontiers in aging …, 2011 - frontiersin.org
The link between central adiposity and cognition has been established by indirect measures
such as body mass index (BMI) or waist–hip ratio. Magnetic resonance imaging (MRI) …

[HTML][HTML] Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological …

R Krishnadas, J McLean, DG Batty, H Burns… - NeuroImage: Clinical, 2013 - Elsevier
Introduction Cardio-metabolic risk factors have been associated with poor physical and
mental health. Epidemiological studies have shown peripheral risk markers to be associated …

Differential associations between systemic markers of disease and cortical thickness in healthy middle-aged and older adults

AM Coutinho, JP Coutu, ER Lindemer, HD Rosas… - NeuroImage, 2017 - Elsevier
Aside from cortical damage associated with age, cerebrovascular and neurodegenerative
diseases, it's an outstanding question if factors of global health, including normal variation in …

Obesity impairs cognitive function via metabolic syndrome and cerebrovascular disease: an SEM analysis in 15,000 adults from the UK Biobank

F Morys, M Dadar, A Dagher - BioRxiv, 2020 - biorxiv.org
Chronic obesity is associated with several complications, including cognitive impairment
and dementia. However, we have piecemeal knowledge of the mechanisms linking obesity …

Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease

RE Green, J Lord, MA Scelsi, J Xu, A Wong… - Alzheimer's research & …, 2023 - Springer
Background Identifying blood-based signatures of brain health and preclinical pathology
may offer insights into early disease mechanisms and highlight avenues for intervention …

A Blood-Based Lipid Profile Associated With Hippocampal Volume and Brain Resting-State Activation Within Obese Adults from the UK Biobank

G Jiang, JS Rabin, SE Black, W Swardfager… - Brain …, 2023 - liebertpub.com
Objectives: Obesity and dyslipidemia may be associated with hippocampal alterations and
may increase the risk of neurodegeneration. This study studied hippocampal anatomical …

Causal role of lipid metabolome on the risk of ischemic stroke, its etiological subtypes, and long-term outcome: A Mendelian randomization study

JM Martín-Campos, J Cárcel-Márquez, L Llucià-Carol… - Atherosclerosis, 2023 - Elsevier
Background and aims The lipid profile is consistently associated with coronary artery
disease (CAD) and ischemic stroke (IS). However, the lipoprotein subfractions have not …