Effects of nonsteroidal anti-inflammatory drugs on the renal excretion of indoxyl sulfate, a nephro-cardiovascular toxin, in rats

CP Yu, DH Sweet, YH Peng, YW Hsieh… - European Journal of …, 2017 - Elsevier
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a
nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through …

Effects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin

SS Luo, CP Yu, YW Hsieh, PDL Chao, DH Sweet… - Xenobiotica, 2020 - Taylor & Francis
Indoxyl sulfate (IS), a highly protein-bound nephro-cardiovascular toxin, was poorly removed
by hemodialysis. IS exists as anions in the body and the renal excretion is mediated by …

In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats

T Fujita, K Ishihara, S Yasuda, T Nakamura… - … of Pharmacology and …, 2012 - ASPET
Indoxyl sulfate (IS) is an organic anion uremic toxin that accumulates in patients with chronic
kidney disease (CKD). The aims of this study were to examine the kinetic profiles of IS in …

Indoxyl sulfate is a nephro-vascular toxin

T Niwa - Journal of Renal Nutrition, 2010 - Elsevier
Indoxyl sulfate is markedly accumulated in the serum of patients with chronic kidney disease
(CKD). The oral sorbent AST-120 reduces the serum levels of indoxyl sulfate in CKD …

Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST‐120

T Niwa - Therapeutic Apheresis and dialysis, 2011 - Wiley Online Library
Indoxyl sulfate, a nephrovascular uremic toxin, is markedly accumulated in the serum of
chronic kidney disease (CKD) patients. Because of its protein binding ability, its removal by …

Association between serum indoxyl sulfate levels and endothelial function in non-dialysis chronic kidney disease

CH Wang, YH Lai, CH Kuo, YL Lin, JP Tsai, BG Hsu - Toxins, 2019 - mdpi.com
Indoxyl sulfate (IS), a product metabolized from tryptophan, is negatively correlated with
renal function and cardiovascular diseases in patients with chronic kidney disease (CKD) …

Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease

CJ Lin, HL Liu, CF Pan, CK Chuang… - Archives of Medical …, 2012 - Elsevier
BACKGROUND AND AIMS: Indoxyl sulfate, a protein-bound uremic toxin, was found to be
accumulated in kidney tissues with a reduction in renal function. This, in turn, not only leads …

Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic …

C Saigo, Y Nomura, Y Yamamoto… - Drug Design …, 2014 - Taylor & Francis
Indoxyl sulfate (IS), a putative low-molecular weight uremic toxin, is excreted in the urine
under normal kidney function, but is retained in the circulation and tissues during renal …

Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients

K Taki, Y Tsuruta, T Niwa - American Journal of Nephrology, 2007 - karger.com
Background: Indoxyl sulfate is a uremic toxin that accelerates the progression of chronic
kidney disease (CKD). Serum levels of indoxyl sulfate are increased in dialysis patients. It …

Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease

K Morimoto, Y Tominaga, Y Agatsuma… - … & drug disposition, 2018 - Wiley Online Library
Indoxyl sulfate (IS) is a protein‐bound uremic toxin that progressively accumulates in plasma
during chronic kidney disease (CKD), and its accumulation is associated with the …