Precision medicine in systemic lupus erythematosus

S Fasano, A Milone, GF Nicoletti, DA Isenberg… - Nature Reviews …, 2023 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

Immune profiling and precision medicine in systemic lupus erythematosus

Y Nagafuchi, H Shoda, K Fujio - Cells, 2019 - mdpi.com
Systemic lupus erythematosus (SLE) is an autoimmune disorder with a wide range of clinical
symptoms. Enormous progress has been made in the immunological and genetic …

Biomarkers for systemic lupus erythematosus: a review and perspective

CC Liu, S Manzi, JM Ahearn - Current opinion in rheumatology, 2005 - journals.lww.com
There is a longstanding and recently rejuvenated enthusiasm for biomarkers that precisely
and specifically reflect the pathophysiologic and clinical changes in systemic lupus …

Advances in systemic lupus erythematosus

SA Yeoh, SS Dias, DA Isenberg - Medicine, 2018 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a
heterogeneous course and systemic involvement. It is the result of a complex pathogenic …

[HTML][HTML] Systemic lupus erythematosus diagnostics in the 'omics' era

C Arriens, C Mohan - International journal of clinical rheumatology, 2013 - ncbi.nlm.nih.gov
Systemic lupus erythematosus is a complex autoimmune disease affecting multiple organ
systems. Currently, diagnosis relies upon meeting at least four out of eleven criteria outlined …

Towards precision medicine in systemic lupus erythematosus

E Lever, MR Alves, DA Isenberg - … and personalized medicine, 2020 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a remarkable condition characterised by diversity
amongst its clinical features and immunological abnormalities. In this review, we attempt to …

Systemic lupus erythematosus biomarkers: the challenging quest

C Arriens, JD Wren, ME Munroe, C Mohan - Rheumatology, 2017 - academic.oup.com
SLE, a multisystem heterogeneous disease, is characterized by production of antibodies to
cellular components, with activation of both the innate and the adaptive immune system …

The main challenges in systemic lupus erythematosus: where do we stand?

M Piga, L Arnaud - Journal of clinical medicine, 2021 - mdpi.com
Systemic lupus erythematosus (SLE) is an immune-mediated multi-systemic disease
characterized by a wide variability of clinical manifestations and a course frequently subject …

[HTML][HTML] Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus

J Lindblom, D Toro-Domínguez… - Journal of …, 2023 - Elsevier
Objectives We aimed at investigating the whole-blood transcriptome, expression quantitative
trait loci (eQTLs), and levels of selected serological markers in patients with SLE versus …

Systemic lupus erythematosus: the search for the ideal biomarker

LA González, MF Ugarte-Gil, GS Alarcón - Lupus, 2021 - journals.sagepub.com
During the last decades, there has been an increased interest in the discovery and
validation of biomarkers that reliably reflect specific aspects of lupus. Although many …