Introduction Overwhelming neutrophil activation and oxidative stress significantly contribute
to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of …

Intracellular levels of cyclic nucleotides are closely regulated by distinct families of PDEs,
which are responsible for the breakdown and degradation of cyclic nucleotides within cells …

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no
effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 …

Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-Roscovitine and AT7519,
induce neutrophil apoptosis in vitro and enhance the resolution of inflammation in a number …

Cytokine storms caused by viruses are associated with elevated cytokine levels and
uncontrolled inflammatory responses that can lead to acute respiratory distress syndrome …

Background Despite all modern advances in medicine, an effective drug for treating sepsis
has yet to be found. The discovery of CMPK2 spurred hopes for the treatment of sepsis …

Background The pathogenesis of acute respiratory distress syndrome (ARDS) is attributed to
the dysregulation of oxidative stress and neutrophil recruitment. We aimed to investigate the …

The population pharmacokinetics (popPK) of ribociclib and population pharmacokinetic/
pharmacodynamic (PK/PD) relationship between ribociclib and absolute neutrophil count …

Apoptosis is essential for clearance of potentially injurious inflammatory cells and
subsequent efficient resolution of inflammation. Here we report that human neutrophils …

In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …