New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

FSG Júnior, JA de Moraes Silveira, TM Holanda… - Dalton …, 2023 - pubs.rsc.org
Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl
(HNO) release, which exert their therapeutic application. In this context, we developed two …

Enhancing vascular relaxing effects of nitric oxide-donor ruthenium complexes

M Paulo, TM Banin, FA de Andrade… - Future medicinal …, 2014 - Taylor & Francis
Ruthenium-derived complexes have emerged as new nitric oxide (NO) donors that may help
circumvent the NO deficiency that impairs vasodilation. NO in vessels can be produced by …

Thiol-activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy

EH Silva Sousa, LA Ridnour, FS Gouveia Jr… - ACS Chemical …, 2016 - ACS Publications
Metallonitrosyl complexes are promising as nitric oxide (NO) donors for the treatment of
cardiovascular, endothelial, and pathogenic diseases, as well as cancer. Recently, the …

Design, reactivity, and biological activity of ruthenium nitrosyl complexes

RS da Silva, RG de Lima… - Advances in Inorganic …, 2015 - Elsevier
Recently, remarkable biological functions have been attributed to nitric oxide (NO) as
responsible to mediate neuronal communication, blood vessel modulation, and immune …

Ru (II) based dual nitric oxide donors: electrochemical and photochemical reactivities and vasorelaxant effect with no cytotoxicity

CDS da Silva, KQ Ferreira, CS Meira… - Dalton …, 2023 - pubs.rsc.org
The synthesized complexes, cis-[Ru (NO)(NO2)(phen) 2](PF6) 2 (NONO2P) and cis-[Ru
(NO)(NO2)(bpy) 2](PF6) 2 (NONO2B), were characterized by using elemental analysis …

New nitric oxide donors based on ruthenium complexes

CN Lunardi, RS Da Silva, LM Bendhack - Brazilian Journal of Medical …, 2009 - SciELO Brasil
Nitric oxide (NO) donors produce NO-related activity when applied to biological systems.
Among its diverse functions, NO has been implicated in vascular smooth muscle relaxation …

[HTML][HTML] Ruthenium complexes as NO donors for vascular relaxation induction

RG De Lima, BR Silva, RS Da Silva, LM Bendhack - Molecules, 2014 - mdpi.com
Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction
is among the several functions of NO, and the administration of NO donors is a …

Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities

GL Sasahara, FSG Júnior… - Journal of Inorganic …, 2020 - Elsevier
Inflammation is a physiological process triggered in response to tissue damage, and
involves events related to cell recruitment, cytokines release and reactive oxygen species …

Understanding of [RuL (ONO)] n+ acting as nitric oxide precursor, a theoretical study of ruthenium complexes of 1, 4, 8, 11-tetraazacyclo-tetradecane having different …

JG Hernández, J Narayanan, EG Hernández… - Journal of Inorganic …, 2021 - Elsevier
Generation of nitric oxide has been a great interest in cell biology as it involves a wide range
of physiological functions including the blood pressure control; thus the exploitation of …

[HTML][HTML] Ruthenium-nitrite complex as pro-drug releases NO in a tissue and enzyme-dependent way

AC Pereira, PC Ford, RS da Silva, LM Bendhack - Nitric Oxide, 2011 - Elsevier
Nitric oxide (NO) plays an important role in the control of the vascular tone and the most
often employed NO donors have limitations due to their harmful side-effects. In this context …