Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients

MCM Villalba, OV Ramírez, MM Jiménez, AA Garcia… - Clinical …, 2020 - Elsevier
Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and
anti-inflammatory mediators plays an important role in the immunopathogenesis of …

[HTML][HTML] mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients

Z Bagheri-Hosseinabadi, E Rezazadeh Zarandi… - BMC infectious …, 2022 - Springer
Background The etiopathogenesis of coronavirus disease 2019 (COVID-19) stem partially
from the abnormal activation of the innate and adaptive immune systems. Here in the current …

[HTML][HTML] In nasal mucosal secretions, distinct IFN and IgA responses are found in severe and mild SARS-CoV-2 infection

JMB Santos, CP Soares, FR Monteiro, R Mello… - Frontiers in …, 2021 - frontiersin.org
Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response,
which includes production and releasing of both cytokines and secretory immunoglobulin …

[HTML][HTML] Differential expression of antiviral and immune-related genes in individuals with COVID-19 asymptomatic or with mild symptoms

M Gajate-Arenas, O García-Pérez… - Frontiers in Cellular …, 2023 - frontiersin.org
COVID-19 is characterized by a wide range of symptoms where the genetic background
plays a key role in SARS-CoV-2 infection. In this study, the relative expression of IRF9 …

Interleukin 6, soluble interleukin 2 receptor alpha (CD25), monocyte colony-stimulating factor, and hepatocyte growth factor linked with systemic hyperinflammation …

L Quartuccio, M Fabris, A Sonaglia, M Peghin… - Cytokine, 2021 - Elsevier
Background Patients infected by SARS-CoV-2 can develop interstitial pneumonia, requiring
hospitalisation or mechanical ventilation. Increased levels of inflammatory biomarkers are …

Nasopharyngeal epithelial cells from patients with coronavirus disease 2019 express abnormal levels of Toll-like receptors

Z Bagheri-Hosseinabadi… - Pathogens and global …, 2023 - Taylor & Francis
Aberrant activation of the immune system has been attributed with etiology and
pathogenesis of coronavirus disease 2019 (COVID-19). Here, the transcript levels of toll-like …

[HTML][HTML] Association between cytokine profiles and lung injury in COVID-19 pneumonia

LD Chen, ZY Zhang, XJ Wei, YQ Cai, WZ Yao… - Respiratory …, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a new respiratory and
systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer

H Shuai, H Chu, Y Hou, D Yang, Y Wang, B Hu… - Journal of Infection, 2020 - Elsevier
Objectives Respiratory and intestinal tract are two primary target organs of SARS-CoV-2
infection. However, detailed characterization of the host-virus interplay in infected human …

[HTML][HTML] Post-COVID-19 patients who develop lung fibrotic-like changes have lower circulating levels of IFN-β but higher levels of IL-1α and TGF-β

C Colarusso, A Maglio, M Terlizzi, C Vitale, A Molino… - Biomedicines, 2021 - mdpi.com
Purpose: SARS-CoV-2 infection induces in some patients a condition called long-COVID-19,
herein post-COVID-19 (PC), which persists for longer than the negative oral-pharyngeal …

[HTML][HTML] Circulating type I interferon levels in the early phase of COVID-19 are associated with the development of respiratory failure

K Nagaoka, H Kawasuji, Y Murai, M Kaneda… - Frontiers in …, 2022 - frontiersin.org
Background The role of type I interferons (IFNs) in the early phase of COVID-19 remains
unclear. Objectives To evaluate the relationship between IFN-I levels in patients with COVID …