[HTML][HTML] Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue

J Moser, M Emous, P Heeringa… - Trends in Endocrinology …, 2023 - cell.com
Obesity is an independent risk factor for severe COVID-19, yet there remains a lack of
consensus on the mechanisms underlying this relationship. A hypothesis that has garnered …

Obesity and COVID-19: mechanistic insights from adipose tissue

L Yu, X Zhang, S Ye, H Lian, H Wang… - The Journal of Clinical …, 2022 - academic.oup.com
Obesity is associated with an increase in morbidity and mortality from coronavirus disease
2019 (COVID-19). The risk is related to the cytokine storm, a major contributor to multiorgan …

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

[HTML][HTML] Exploring the network between adipocytokines and inflammatory response in SARS-CoV-2 infection: a scoping review

E Nigro, V D'Agnano, G Quarcio, DF Mariniello… - Nutrients, 2023 - mdpi.com
Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that
merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as …

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

GJ Martínez-Colón, K Ratnasiri, H Chen, S Jiang… - bioRxiv, 2021 - biorxiv.org
The COVID-19 pandemic, caused by the viral pathogen SARS-CoV-2, has taken the lives of
millions of individuals around the world. Obesity is associated with adverse COVID-19 …

[HTML][HTML] Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response

A Basolo, AM Poma, D Bonuccelli, A Proietti… - Journal of …, 2022 - Springer
Objective Obesity is a recognized risk factor for the progression to severe forms of COVID-
19, yet the mechanisms of the association are unclear. Methods Subcutaneous abdominal …

Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?

JJ Zhu, JPH Wilding, J Hu - Medical Hypotheses, 2023 - Elsevier
Research evidence suggests that adipocytes in obesity might facilitate SARS-CoV-2
replication, for it was only found in adipose tissue of individuals with overweight or obesity …

[HTML][HTML] SARS-CoV-2 infects adipose tissue in a fat depot-and viral lineage-dependent manner

TD Saccon, F Mousovich-Neto, RG Ludwig… - Nature …, 2022 - nature.com
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …

[HTML][HTML] Obesity as an adipose tissue dysfunction disease and a risk factor for infections–Covid-19 as a case study

MF Landecho, M Marin-Oto… - European journal of …, 2021 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-
19) is a novel threat that hampers life expectancy especially in obese individuals. Though …

Do adipocytes serve as a reservoir for severe acute respiratory syndrome coronavirus-2?

C Steenblock, N Bechmann… - Journal of …, 2023 - joe.bioscientifica.com
Obesity is associated with a higher risk of severe coronavirus disease 2019 (COVID-19) and
increased mortality. In the current study, we have investigated the expression of ACE2 …