Endothelial cell plasticity at the single-cell level

A Pasut, LM Becker, A Cuypers, P Carmeliet - Angiogenesis, 2021 - Springer
The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …

Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives

LM Becker, SH Chen, J Rodor… - Cardiovascular …, 2023 - academic.oup.com
Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …

Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration

DJ Nolan, M Ginsberg, E Israely, B Palikuqi… - Developmental cell, 2013 - cell.com
Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …

Metabolic signatures of distinct endothelial phenotypes

SJ Dumas, M García-Caballero, P Carmeliet - Trends in Endocrinology & …, 2020 - cell.com
Angiogenesis is crucial for the development of the blood vasculature during embryogenesis,
but also contributes to cancer and other diseases. While therapeutic targeting of endothelial …

Organ-specific endothelial cell differentiation and impact of microenvironmental cues on endothelial heterogeneity

L Gifre-Renom, M Daems, A Luttun… - International journal of …, 2022 - mdpi.com
Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …

Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

J Goveia, P Stapor, P Carmeliet - EMBO molecular medicine, 2014 - embopress.org
The endothelium is the orchestral conductor of blood vessel function. Pathological blood
vessel formation (a process termed pathological angiogenesis) or the inability of endothelial …

Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling

M Reiterer, CM Branco - The FEBS Journal, 2020 - Wiley Online Library
The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

The diversity of endothelial cells: a challenge for therapeutic angiogenesis

EM Conway, P Carmeliet - Genome biology, 2004 - Springer
Vascular endothelia comprise a diverse population of cells that specialize in response to
genetic programs and environmental cues to take on distinct roles in different vessels …