Aims We investigated the stage-specific mechanisms of partial resistance to artemisinin
(ART, an antimalarial drug) in Plasmodium falciparum (P. falciparum) carrying the Kelch13 …

Emerging resistance against artemisinin (ART) poses a major challenge in controlling
malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are …

The emergence and spread of artemisinin-tolerant malaria parasites threatens malaria
control programmes worldwide. Mutations in the propeller domain of the Kelch13 protein …

Plasmodium falciparum infects millions and kills thousands of people annually the world
over. With the emergence of artemisinin and/or multidrug resistant strains of the pathogen, it …

Despite several setbacks in the fight against malaria such as insecticide and drug resistance
as well as low efficacy of available vaccines, considerable success in reducing malaria …

The ring-stage survival assay was utilized to assess the impact of physiological hyperoxic
stress on dihydroartemisinin (DHA) tolerance for a panel of Plasmodium falciparum strains …

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs)
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …

The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …