In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine
kinase (RTK) in brain development and how perturbation of MET signaling may alter normal …

The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene
comes from convergent genetic, clinical, and developmental neurobiology data. Here, we …

As more genes conferring risks to neurodevelopmental disorders are identified, translating
these genetic risk factors into biological mechanisms that impact the trajectory of the …

Met receptor tyrosine kinase signaling regulates the growth and development of axons and
may contribute to the wiring of cortical and limbic circuits in the rodent forebrain. Whether the …

Background Our laboratory discovered that the gene encoding the receptor tyrosine kinase,
MET, contributes to autism risk. Expression of MET is reduced in human postmortem …

ABSTRACT MET, a replicated autism risk gene, encodes a pleiotropic receptor tyrosine
kinase implicated in multiple cellular processes during development and following injury …

The human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is
implicated in the structural and functional integrity of brain. MET encodes a receptor tyrosine …

Human genetic studies established MET gene as a risk factor for autism spectrum disorders.
We have previously shown that signaling mediated by MET receptor tyrosine kinase …

MET receptor tyrosine kinase (MET)-mediated signaling has been implicated in multiple
aspects of neocortical and cerebellar neuronal growth and maturation. A promoter functional …

The establishment of appropriate neural circuitry depends on the coordination of multiple
developmental events across space and time. These events include proliferation, migration …