HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …

Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets

ZO Serebrovska, EY Chong, TV Serebrovska… - Acta Pharmacologica …, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat …

Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

M Jahani, S Dokaneheifard, K Mansouri - Journal of inflammation, 2020 - Springer
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

S Appelberg, S Gupta… - Emerging microbes & …, 2020 - Taylor & Francis
How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage
cellular host pathways and innate immunity in infected cells remains largely elusive. We …

[PDF][PDF] ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway

X Lin, B Fu, S Yin, Z Li, H Liu, H Zhang, N Xing, Y Wang… - Iscience, 2021 - cell.com
Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great
challenges to the world. More and more studies have shown that patients with severe …

Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

K Taniguchi-Ponciano, E Vadillo, H Mayani… - Annals of …, 2021 - Taylor & Francis
Background COVID-19 counts 46 million people infected and killed more than 1.2 million.
Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is …

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …

Role of IFN and complements system: innate immunity in SARS-CoV-2

T Shibabaw, MD Molla, B Teferi… - Journal of inflammation …, 2020 - Taylor & Francis
The critical role of the innate immune system has been confirmed in driving local and
systemic inflammation and the cytokine release storm in severe acute respiratory syndrome …