Microbiota alterations in proline metabolism impact depression

J Mayneris-Perxachs, A Castells-Nobau… - Cell metabolism, 2022 - cell.com
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing …

Prebiotic and probiotic modulation of the microbiota–gut–brain axis in depression

DE Radford-Smith, DC Anthony - Nutrients, 2023 - mdpi.com
Emerging evidence demonstrates that alterations to the gut microbiota can affect mood,
suggesting that the microbiota–gut–brain (MGB) axis contributes to the pathogenesis of …

[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

The neuroactive potential of the human gut microbiota in quality of life and depression

M Valles-Colomer, G Falony, Y Darzi… - Nature …, 2019 - nature.com
The relationship between gut microbial metabolism and mental health is one of the most
intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut …

Probiotics for the treatment of depression and its comorbidities: A systemic review

J Gao, L Zhao, Y Cheng, W Lei, Y Wang… - Frontiers in Cellular …, 2023 - frontiersin.org
Depression is one of the most common psychiatric conditions, characterized by significant
and persistent depressed mood and diminished interest, and often coexists with various …

Current perspectives on gut microbiome dysbiosis and depression

A Capuco, I Urits, J Hasoon, R Chun, B Gerald… - Advances in …, 2020 - Springer
The human gut microbiome partakes in a bidirectional communication pathway with the
central nervous system (CNS), named the microbiota–gut–brain axis. The microbiota–gut …

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Crosstalk between the microbiota-gut-brain axis and depression

Y Du, XR Gao, L Peng, JF Ge - Heliyon, 2020 - cell.com
Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to
depression, has become a promising research field over the past several decades. An …

Toward a deeper understanding of gut microbiome in depression: the promise of clinical applicability

L Liu, H Wang, H Zhang, X Chen, Y Zhang… - Advanced …, 2022 - Wiley Online Library
The emergence of the coronavirus disease 2019 pandemic has dramatically increased the
global prevalence of depression. Unfortunately, antidepressant drugs benefit only a small …

Inflammation, lifestyle factors, and the microbiome‐gut‐brain Axis: relevance to depression and antidepressant action

F Donoso, JF Cryan… - Clinical …, 2023 - Wiley Online Library
Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …