Evolution of Sequence and Structure of SARS-CoV-2 Spike Protein: A Dynamic Perspective

A Sinha, S Sangeet, S Roy - ACS omega, 2023 - ACS Publications
Novel coronavirus (SARS-CoV-2) enters its host cell through a surface spike protein. The
viral spike protein has undergone several modifications/mutations at the genomic level …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and …

[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

[HTML][HTML] A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features

S Fatihi, S Rathore, AK Pathak, D Gahlot… - Current Research in …, 2021 - Elsevier
The recent release of SARS-CoV-2 genomic data from several countries has provided clues
into the potential antigenic drift of the coronavirus population. In particular, the genomic …

The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play

PFN Souza, FP Mesquita, JL Amaral… - International Journal of …, 2021 - Elsevier
Three coronaviruses (CoVs) have threatened the world population by causing outbreaks in
the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 …

[HTML][HTML] Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

J Trigueiro-Louro, V Correia, I Figueiredo-Nunes… - Computational and …, 2020 - Elsevier
There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The
beta-CoV Spike protein is a promising target considering the critical role in viral infection …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

[HTML][HTML] Taking stock of the mutations in human SARS-CoV-2 spike proteins: From early days to nearly the end of COVID-19 pandemic

L Guruprasad, GKRS Naresh, G Boggarapu - Current Research in …, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causative agent of the
coronavirus disease-2019 (COVID-19) has resulted in several deaths and severe economic …

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies

S Pokhrel, BR Kraemer, S Burkholz… - Scientific reports, 2021 - nature.com
In December 2019, a novel coronavirus, termed severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was identified as the cause of pneumonia with severe …