M6A regulatory genes play an important role in the prognosis, progression and immune microenvironment of pancreatic adenocarcinoma

F Xu, Z Zhang, M Yuan, Y Zhao, Y Zhou, H Pei… - Cancer …, 2021 - Taylor & Francis
The specific roles of N6-methyladenosine (m6A) regulatory genes in pancreatic
adenocarcinoma (PAAD) have not been fully elucidated. In present study, a novel risk …

The role of m6A-related genes in the prognosis and immune microenvironment of pancreatic adenocarcinoma

R Tang, Y Zhang, C Liang, J Xu, Q Meng, J Hua, J Liu… - PeerJ, 2020 - peerj.com
Background Pancreatic adenocarcinoma (PAAD) is among the most lethal diseases and has
a dismal prognosis; however, efficient treatment is currently limited. Several studies have …

N6-methyladenosine methylation modification patterns reveal immune profiling in pancreatic adenocarcinoma

H Xu, L Yin, Q Xu, J Xiang, R Xu - Cancer cell international, 2022 - Springer
Background Several studies have revealed that N6-methyladenosine (m6A) regulation is
involved in various biological processes and cancer progression. Nevertheless, the potential …

An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer

Z Zhou, J Zhang, C Xu, J Yang, Y Zhang, M Liu, X Shi… - …, 2021 - thelancet.com
Abstract Background N6-methyladenosine (m6A) is the most abundant mRNA modification.
Whether m6A regulators can determine tumor aggressiveness and risk of immune evasion …

METTL16 predicts a favorable outcome and primes antitumor immunity in pancreatic ductal adenocarcinoma

L Lu, D Zheng, J Qu, Y Zhuang, J Peng… - Frontiers in Cell and …, 2022 - frontiersin.org
Pancreatic carcinogenesis is a complicated and multi-step process. It is substantially
assisted by N6-methyladenosine (m6A) RNA modification, especially when mutations of …

m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Pancreatic Cancer

M Sun, M Xie, T Zhang, Y Wang, W Huang… - Frontiers in …, 2021 - frontiersin.org
Recent studies have shown that RNA N6-methyladenosine (m6A) modification plays an
important part in tumorigenesis and immune-related biological processes. However, the …

Gene Signature and Identification of Clinical Trait-Related m6 A Regulators in Pancreatic Cancer

J Hou, Z Wang, H Li, H Zhang, L Luo - Frontiers in genetics, 2020 - frontiersin.org
Pancreatic cancer (PC) has a very poor prognosis and is usually diagnosed only at an
advanced stage. The discovery of new biomarkers for PC will help in early diagnosis and a …

An m6A-related prognostic biomarker associated with the hepatocellular carcinoma immune microenvironment

Y Du, Y Ma, Q Zhu, T Liu, Y Jiao, P Yuan… - Frontiers in …, 2021 - frontiersin.org
Background: N6-methyladenosine (m6A) is related to the progression of multiple cancers.
However, the underlying influences of m6A-associated genes on the tumor immune …

[HTML][HTML] N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular …

S Shen, J Yan, Y Zhang, Z Dong, J Xing… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background N6-methyladenosine (m6A)-mediated ribonucleic acid (RNA) methylation is
considered to be the most significant and abundant epigenetic modification in eukaryotic …

Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic …

L Wang, S Zhang, H Li, Y Xu, Q Wu, J Shen, T Li, Y Xu - BMC cancer, 2021 - Springer
Background m6A is the most prevalent and abundant form of mRNA modifications and is
closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try …